One of the most common complications of diabetes is the development of peripheral neuropathy. Along with the retina in the eye and the kidney, the nervous system is particularly vulnerable to unregulated glucose levels in the blood. This is because glucose, or free sugar in the blood, is able to freely move in and out of these cells without the use of glucose receptors.
Diabetic neuropathy comes in a variety of forms, depending on which nerves are involved. The sensory, motor, and autonomic (involuntary) nervous systems are all affected in diabetic neuropathy, but the sensory involvement is usually the first to become noticeably symptomatic. This often begins with a burning, tingling, or feeling of numbness in the feet. This may also occur in the hands at the same time. This pattern of distribution is commonly referred to as the “stocking-and-glove” distribution. Many theorize that the longest nerves are the first to be affected by peripheral neuropathy, hence the involvement of the hands and feet first. The pain is generally worse at night or at rest.
While the symptoms of numbness and pain of a burning or tingling nature may be uncomfortable, the later sequalae of peripheral neuropathy is certainly more of concern. Once the sensation in the feet is diminished or absent, the foot becomes prone to injury. This injury may go completely unnoticed, which can lead to an open, infected wound. Ulcerations secondary to diabetic peripheral neuropathy cause enormous amounts of morbidity, and can become complicated by systemic infections.
Signs of motor neuropathy in the diabetic patient include structural changes to the foot due to a loss of intrinsic musculature. This may include hammering of the digits, as well as a noticeable loss of the abductor hallucis, a muscle found on the inside (medial) of the foot near the arch. These changes may be more subtle than the subjective findings of pain due to sensory neuropathy.
Autonomic neuropathy also causes changes to the foot that can be appreciated on physical examination. Findings such as lack of hair growth to the digits, changes to the skin color or texture, changes in warmth, and decreased circulation to the foot can all be signs of autonomic neuropathy in the diabetic patient.
Unfortunately, there is no cure for diabetic neuropathy. The onset and progression of symptoms can be avoided by keeping tight control of blood glucose levels. Avoiding hyperglycemic events will prevent the nerves from being damaged by excessive glucose in the blood. In fact, many diabetics report an increase in pain after eating a carbohydrate-rich meal or if their glucose levels are running high.
Drugs that have been used to treat painful diabetic peripheral neuropathy are targeted at the symptoms rather than at the cause. This includes antidepressants such as amitryptiline or nortriptyline, gabapentin, topical capsaicin, and sedatives and pain relievers such as opiates.
A podiatrist will screen for neuropathy in diabetic patients. This is often a very simple, noninvasive test in the office where the protective sensation in the feet is tested. Further testing may be warranted for borderline cases, but is typically unnecessary. If you are diabetic and are concerned about peripheral neuropathy, have a discussion with your podiatrist or primary doctor today.
Hi, I work with Metanx. We are so glad to see people talking about this important issue. While there may be no "cure," there are treatment options beyond pallitive therapies. Metanx provides nutritional management of endothelial dysfunction. Metanx addresses the underlying pathology of the disease, so it improves not only painful symptoms but also restores sensory loss. Patients have seen improvement in 1 week to 4 months. Patients afflicted with diabetic neuropathy should to their doctor about this treatment option for diabetic neuropathy.
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